|+1 404 474 4654|
|+1 888 205 9894 (TF)|
CAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
|Synonyms||CREB, MGC9284, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, JAL, hJAL, ATCE1, CREB3, CREB4, AIBZIP, CREB1, creb1, MGC52669, creb, MGC69285, MGC55598, zgc:55598, Creb1, DKFZp468J2311|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|5 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This Phospho-CREB-S133 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.|
|Description||Other names: cAMP response element-binding protein, CREB, CREB1,|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Phospho-CREB-S133 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.|
|Molecular Weight||36688 DA|
Background: CREB is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, (CRE), a sequence present in many viral and cellular promoters. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein G affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylate|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Perry, Sklan, Soreq: "CREB regulates AChE-R-induced proliferation of human glioblastoma cells." in: Neoplasia (New York, N.Y.), Vol. 6, Issue 3, pp. 279-86, 2004 (PubMed).
Cho, Choi, Kim et al.: "Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6676-81, 2005 (PubMed).
Bailey, Tyson-Capper, Gilmore et al.: "Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins." in: Journal of molecular endocrinology, Vol. 34, Issue 1, pp. 1-17, 2005 (PubMed).
Zhang, Odom, Koo et al.: "Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 12, pp. 4459-64, 2005 (PubMed).
Samten, Howard, Weis et al.: "Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 10, pp. 6357-63, 2005 (PubMed).