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Details for Product No. ABIN389547

CAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody

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Antigen
Synonyms CREB, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, creb, creb1, zgc:55598, CREB1, Creb1
Epitope
»Alternatives pSer133
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN389547
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CREB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.
Clone RB05198
Isotype Ig
Specificity This Phospho-CREB-S133 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CREB
Background CREB is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, (CRE), a sequence present in many viral and cellular promoters. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.
Synonyms: cAMP response element-binding protein, CREB, CREB1,
Molecular Weight 36688 DA
Gene ID 1385
UniProt P16220
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Perry, Sklan, Soreq: "CREB regulates AChE-R-induced proliferation of human glioblastoma cells." in: Neoplasia (New York, N.Y.), Vol. 6, Issue 3, pp. 279-86, 2004 (PubMed).

Cho, Choi, Kim et al.: "Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6676-81, 2005 (PubMed).

Bailey, Tyson-Capper, Gilmore et al.: "Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins." in: Journal of molecular endocrinology, Vol. 34, Issue 1, pp. 1-17, 2005 (PubMed).

Zhang, Odom, Koo et al.: "Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 12, pp. 4459-64, 2005 (PubMed).

Samten, Howard, Weis et al.: "Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 10, pp. 6357-63, 2005 (PubMed).

Alternatives for antigen "CAMP Responsive Element Binding Protein 1 (CREB1)", type "Antibodies"
Hosts (284), (58), (1)
Reactivities (323), (228), (215), (75), (69), (68), (45), (8), (6), (6), (5), (1), (1), (1)
Applications (249), (129), (110), (84), (60), (36), (32), (20), (9), (3), (2), (2), (2), (2), (2), (1), (1)
Conjugates (9), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (74), (35), (24), (20), (14), (9), (7), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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