anthrax Toxin Receptor 1 (ANTXR1) (pTyr382) antibody

Details for Product No. ABIN389930
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Antigen
Synonyms ANTXR1, ATR, TEM8, 2310008J16Rik, 2810405N18Rik, Antrx1, Tem8
Epitope
pTyr382
(15), (15), (8), (6), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(102), (44), (40), (13), (12), (1)
Host
Rabbit
(94), (8), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Dot Blot (DB)
(57), (41), (25), (20), (18), (13), (11), (4), (2), (2), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN389930
291.50 $
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Immunogen This ANTXR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y382 of human ANTXR1.
Clone RB15324
Isotype Ig
Specificity This Phospho-ANTXR1-pY382 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 365~394 amino acids surrounding Y382 of human ANTXR1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ANTXR1
Background ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Synonyms: Anthrax toxin receptor 1 [Precursor], Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Molecular Weight 62789 DA
Gene ID 84168
UniProt Q9H6X2
Research Area Cell Signaling, Cancer, Phospho-specific antibodies, Cell Structure
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-anthrax Toxin Receptor 1 (ANTXR1) (pTyr382) antibody Dot blot analysis of anti-Phospho-ANTXR1-pY382 Antibody (ABIN389930) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
Background publications Rainey, Wigelsworth, Ryan et al.: "Receptor-specific requirements for anthrax toxin delivery into cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13278-83, 2005 (PubMed).

Wei, Lu, Chaudry et al.: "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin." in: Cell, Vol. 124, Issue 6, pp. 1141-54, 2006 (PubMed).

Werner, Kowalczyk, Faundez: "Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23227-36, 2006 (PubMed).

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