ABCB7 antibody (C-Term)

Catalog No. ABIN390062

The Rabbit Polyclonal anti-ABCB7 antibody is suitable to detect ABCB7 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for ABCB7 antibody (C-Term) (ABIN390062)

Target: ABCB7 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCB7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1811

Product Details anti-ABCB7 Antibody

Binding Specificity: AA 718-746, C-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ABCB7

Target: ABCB7 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7))

Alternative Name: ABCB7

Background: The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

Molecular Weight: 82641

Gene ID: 22

NCBI Accession: NP_001258625, NP_001258627, NP_004290

UniProt: O75027

Pathways: Transition Metal Ion Homeostasis