|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term) antibody
|Synonyms||MMP14, MMP-14, mmp-x1, mtmmp1, mt1-mmp, MGC69200|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.|
|Description||Other names: Matrix metalloproteinase-14 [Precursor], MMP-14, EC 184.108.40.206, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP-X1, MMP14|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.|
|Molecular Weight||65883 DA|
Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100 Flow cytometric~~1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Protein Modifications, Cell Structure, Cancer|
|Restrictions||For Research Use only|
Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).
Okada, Bellocq, Rouyer et al.: "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2730-4, 1995 (PubMed).
Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).