Regulator of Calcineurin 1 (RCAN1) (C-Term) antibody

Antigen: Regulator of Calcineurin 1 (RCAN1)

Synonyms: RCAN1, dscr1, wu:fr92c05, csp1, dsc1, mcip1, adapt78, MGC68988, MGC53636, LOC443255, DSCR1, rcn1, MGC69428, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, MGC128596, DKFZp469I0324

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN390298

Additional Information

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Alternative name: DSCR1 (C-term)

Gene ID: 1827

Swiss-Prot: Q7Z555

Immunogen: This DSCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175~204 amino acids from the C-terminal region of human DSCR1.

Isotype: Ig  (Matching secondary antibodies)

Description: Other names: Calcipressin 1, DSCR1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, DSC1

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DSCR1.

Molecular Weight: 28079 DA

Synonyms: RCAN1, dscr1, wu:fr92c05, csp1, dsc1, mcip1, adapt78, MGC68988, MGC53636, LOC443255, DSCR1, rcn1, MGC69428, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, MGC128596, DKFZp469I0324

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology, Cell Structure

Restrictions: For Research Use only

Images

The anti-DSCR1 Pab (ABIN390298) is used in Western blot to detect DSCR1 in endothelial tissue lysate.

Endothelial cell lysate transferred to membrane was incubated with primary antibody at a 1:500 dilution in 2% BSA in TBST at 4° C overnight. Data courtesy of Dr. Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor.

Publications

Publications: Yang, Chen, Edgar et al.: "Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 195-207, 2009 (PubMed).

Hirakawa, Nary, Medh: "Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis." in: Journal of molecular signaling, Vol. 4, pp. 6, 2009 (PubMed).