Parkin antibody (N-Term)

Catalog No. ABIN390365

The Rabbit Polyclonal anti-Parkin antibody is suitable to detect Parkin in samples from Human. It has been validated for WB.

Quick Overview for Parkin antibody (N-Term) (ABIN390365)

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Parkin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB7371

Product Details anti-Parkin Antibody

Binding Specificity: AA 111-140, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the N-terminal region of human Parkin.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:250-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Parkin

Target: Parkin (PARK2) (Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))

Alternative Name: Parkin

Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.

Molecular Weight: 51641

Gene ID: 5071

NCBI Accession: NP_004553, NP_054642, NP_054643

UniProt: O60260

Pathways: Autophagy, Ubiquitin Proteasome Pathway