Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated serine Esterase 1) (Gzmb) (C-Term), (AA 175-203) antibody

Details for Product No. ABIN390496
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Antigen
Epitope
C-Term, AA 175-203
(31), (14), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(147), (49), (34), (12), (12), (4), (3), (2), (2)
Host
Rabbit
(85), (66), (9), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(10), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(76), (60), (45), (33), (29), (17), (14), (13), (10), (8), (6), (2), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN390496
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Immunogen This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 AA from the C-terminal region of human GZMB.
Clone RB19353
Isotype Ig
Specificity This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182~211 amino acids from the C-terminal region of human GZMB.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GZMB
Background Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
Synonyms: Granzyme B, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11, GRB, CTLA1, CSPB, CGL1, GZMB
Molecular Weight 27688 DA
Gene ID 3002
UniProt P10144
Research Area Apoptosis/Necrosis
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated serine Esterase 1) (Gzmb) (C-Term), (AA 175-203) antibody Western blot analysis of GZMB Antibody (C-term) (ABIN390496) in HL-60 cell line lysates (35 µg/lane). GZMB (arrow) was detected using the purified polyclonal antibody.
anti-Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated serine Esterase 1) (Gzmb) (C-Term), (AA 175-203) antibody (2) GZMB Antibody (C-term) (ABIN390496) IHC analysis in formalin fixed and paraffin embedded human Lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated serine Esterase 1) (Gzmb) (C-Term), (AA 175-203) antibody (3) GZMB Antibody (C-term) (ABIN390496) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Gaafar, Aljurf, Al-Sulaiman et al.: "Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients." in: Experimental hematology, Vol. 37, Issue 7, pp. 838-48, 2009 (PubMed).

Girnita, Webber, Brooks et al.: "Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms." in: Transplantation, Vol. 87, Issue 12, pp. 1801-6, 2009 (PubMed).

Hagn, Schwesinger, Ebel et al.: "Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 3, pp. 1838-45, 2009 (PubMed).

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