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GZMB antibody (Granzyme B) Primary Antibody

GZMB Reactivity: Human, Mouse, Rat ELISA, ICC, IF, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262072
$390.77
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  • Target See all GZMB Antibodies
    GZMB
    Reactivity
    • 123
    • 45
    • 34
    • 12
    • 4
    • 3
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 76
    • 47
    • 2
    Rabbit
    Clonality
    • 78
    • 47
    Polyclonal
    Conjugate
    • 79
    • 13
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GZMB antibody is un-conjugated
    Application
    • 71
    • 44
    • 36
    • 33
    • 22
    • 22
    • 18
    • 10
    • 7
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Granzyme B antibody detects endogenous levels of total Granzyme B
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human Granzyme B
    Isotype
    IgG
  • Application Notes
    WB: 1:500~1:3000 IHC: 1:50~1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    GZMB
    Alternative Name
    Granzyme B (GZMB Products)
    Synonyms
    CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, GZMB
    Background

    Description: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

    Gene: GZMB

    Molecular Weight
    28kDa
    Gene ID
    3002
    UniProt
    P10144, P20718
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis
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