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GZMB antibody (Granzyme B) (AA 73-187) Primary Antibody

GZMB Reactivity: Human IHC, StM, WB Host: Mouse Monoclonal GZMB-3014 unconjugated
Catalog No. ABIN6939591
$537.38
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  • Target See all GZMB Antibodies
    GZMB
    Binding Specificity
    • 17
    • 12
    • 12
    • 11
    • 10
    • 9
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 73-187
    Reactivity
    • 123
    • 46
    • 35
    • 12
    • 4
    • 3
    • 2
    • 1
    Human
    Host
    • 77
    • 46
    • 2
    Mouse
    Clonality
    • 79
    • 46
    Monoclonal
    Conjugate
    • 79
    • 13
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GZMB antibody is un-conjugated
    Application
    • 71
    • 44
    • 37
    • 33
    • 22
    • 22
    • 19
    • 10
    • 8
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM), Western Blotting (WB)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)
    Clone
    GZMB-3014
    Isotype
    IgG2b kappa
  • Application Notes

    Positive Control: A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).

    Known Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    GZMB
    Alternative Name
    GZMB (GZMB Products)
    Synonyms
    CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, GZMB
    Background
    Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.
    Molecular Weight
    29-32kDa
    Gene ID
    3002
    UniProt
    P10144
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis
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