Bicaudal C Homolog 1 (Drosophila) (BICC1) (N-Term) antibody

Antigen: Bicaudal C Homolog 1 (Drosophila) (BICC1)

Synonyms: DKFZp686I21119, bpk, jcpk, Bic-C, MGC124370, bic-c, xBic-C, x-Bic-C, bicc1-b, Bicaudal-C

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN390954

Additional Information

Alternative name: BICC1

Gene ID: 80114

UniProt: Q9H694

Immunogen: This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86~116 amino acids from the N-terminal region of human BICC1.

Isotype: Ig

Description: Other names: Protein bicaudal C homolog 1, Bic-C, BICC1

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86~116 amino acids from the N-terminal region of human BICC1.

Molecular Weight: 104844 DA

Comments:

Background: BICC1 is an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Neurology

Restrictions: For Research Use only

Images

Western blot analysis of BICC1 Antibody (N-term) (ABIN390954) in HL-60 cell line lysates (35ug/lane). BICC1 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human brain tissue reacted with BICC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. clinical relevance has not been evaluated.

Publications

Product: Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).