MSK2 antibody (C-Term)

Catalog No. ABIN390994

This Rabbit Polyclonal antibody specifically detects MSK2 in WB. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for MSK2 antibody (C-Term) (ABIN390994)

Target: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSK2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB1020

Product Details anti-MSK2 Antibody

Binding Specificity: AA 322-354, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RSKB (MSK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-354 amino acids from the C-terminal region of human RSKB (MSK2).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MSK2 antibody (ABIN390994)

Lee, McCool, Murdoch, Fritsch et al.: "Dynamic changes in histone H3 phosphoacetylation during early embryonic stem cell differentiation are directly mediated by mitogen- and stress-activated protein kinase 1 via activation of MAPK ..." in: The Journal of biological chemistry, Vol. 281, Issue 30, pp. 21162-72, (2006) (PubMed).

Target Details for MSK2

Target: MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))

Alternative Name: RSKB (MSK2)

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).

Molecular Weight: 85606

Gene ID: 8986

NCBI Accession: NP_001006945, NP_003933

UniProt: O75676