STRADA antibody (N-Term)

Catalog No. ABIN391217

The Rabbit Polyclonal anti-STRADA antibody has been validated for WB, IF and FACS. It is suitable to detect STRADA in samples from Human.

Quick Overview for STRADA antibody (N-Term) (ABIN391217)

Target: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STRADA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: RB8539

Product Details anti-STRADA Antibody

Binding Specificity: AA 12-41, N-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LYK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-41 amino acids from the N-terminal region of human LYK5.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:2000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for STRADA

Target: STRADA (STE20-Related Kinase Adaptor alpha (STRADA))

Alternative Name: LYK5

Background: LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.

Molecular Weight: 48369

Gene ID: 92335

NCBI Accession: NP_001003786, NP_001003787, NP_001003788, NP_001159441, NP_001159442, NP_699166

UniProt: Q7RTN6

Pathways: AMPK Signaling