Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 (APPBP2) (Center) antibody

Antigen: Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 (APPBP2)

Synonyms: PAT1, HS.84084, KIAA0228, AI465480, 1300003O07Rik, zgc:76971, wu:fb78e11, wu:fc25c09, appbp2, MGC80763, APPBP2, DKFZp459F0530

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN391423

Additional Information

Alternative name: PAT1 (APPBP2)

Gene ID: 10513

UniProt: NP_006371

Immunogen: This PAT1(APPBP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249~279 amino acids from the Center region of human PAT1.

Isotype: Ig

Description: Other names: Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2, APP-BP2, Protein interacting with APP tail 1, APPBP2, KIAA0228, PAT1

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PAT1(APPBP2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249~279 amino acids from the Center region of human PAT1.

Molecular Weight: 66722 DA

Comments:

Background: APPBP2 interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This protein has been found to be highly expressed in breast cancer.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure, Neurology

Restrictions: For Research Use only

Images

Western blot analysis of anti-PAT1 (APPBP2) Antibody (Center) (ABIN391423) in HL60 cell line lysates (35ug/lane). PAT1(arrow) was detected using the purified Pab (1:60 dilution).

Publications

Product: Zheng, Eastman, Vande Pol et al.: "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14745-50, 1999 (PubMed).