BCL6 Co-Repressor (BCOR) (Center,Ser1122) antibody

Antigen: BCL6 Co-Repressor (BCOR)

Synonyms: MAA2, ANOP2, MCOPS2, FLJ20285, FLJ38041, KIAA1575, MGC71031, MGC131961, RGD1562735, BCOR

Binding Site: Center,Ser1122

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN391538

Additional Information

Alternative name: BCOR

Gene ID: 54880

UniProt: Q6W2J9

Immunogen: This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1115~1144 amino acids from the Center region of human BCOR.

Isotype: Ig

Description: Other names: BCL-6 corepressor, BCoR , KIAA1575, BCOR

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This BCOR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1115~1144 amino acids from the Center region of human BCOR.

Molecular Weight: 192189 DA

Comments:

Background: BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Apoptosis/Necrosis

Restrictions: For Research Use only

Images

Western blot analysis of BCOR Antibody (Center S1122) (ABIN391538) in 293 cell line lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.

Western blot analysis of BCOR Antibody (Center S1122) (ABIN391538) in mouse stomach tissue lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.

BCOR Antibody (Center S1122) (ABIN391538) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCOR Antibody (Center S1122) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Hilton, Manson, Urquhart et al.: "Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination." in: Human molecular genetics, Vol. 16, Issue 14, pp. 1773-82, 2007 (PubMed).

Ghetu, Corcoran, Cerchietti et al.: "Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer." in: Molecular cell, Vol. 29, Issue 3, pp. 384-91, 2008 (PubMed).