|+1 404 474 4654|
|+1 888 205 9894 (TF)|
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) (C-Term) antibody
|Synonyms||MRP4, MOATB, MOAT-B, EST170205, Mrp4, D630049P08Rik|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1124~1153 amino acids from the C-terminal region of human ABCC4.|
|Description||Other names: Multi-specific organic anion transporter B, MOAT-B, MRP/cMOAT-related ABC transporter, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, ABCC4, MRP4|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1124~1153 amino acids from the C-terminal region of human ABCC4.|
|Molecular Weight||149527 DA|
Background: ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
|Western blot analysis of anti-ABCC4 Antibody (C-term) (ABIN391639) in CEM cell line lysates (35ug/lane). ABCC4 (arrow) was detected using the purified Pab.|
Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).
Lee, Belinsky, Bell et al.: "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." in: Cancer research, Vol. 58, Issue 13, pp. 2741-7, 1998 (PubMed).
Adachi, Sampath, Lan et al.: "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38998-9004, 2002 (PubMed).
|Hosts||Rabbit (25), Goat (7), Rat (5), Mouse (4)|
|Reactivities||Human (40), Mouse (Murine) (21), Rat (Rattus) (20), Chicken (18), Cow (Bovine) (18), Guinea Pig (18), Horse (Equine) (18), Pig (Porcine) (18)|
|Applications||Western Blotting (WB) (23), Immunofluorescence (IF) (21), ELISA (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), Immunocytochemistry (ICC) (5), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Flow Cytometry (FACS) (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (4), AA 1-110 (1), AA 1249-1268 (1), N-Term (1)|