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CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) (AA 9-26) antibody

Details for Product No. ABIN401325, Supplier: Login to see
Antigen
  • CTCFL
  • BORIS
  • CT27
  • CTCF-T
  • HMGB1L1
  • dJ579F20.2
  • Boris
  • OTTMUSG00000016680
Epitope
AA 9-26
7
4
1
1
1
1
Reactivity
Chimpanzee, Human
44
26
24
1
Host
Rabbit
48
2
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
38
11
10
10
8
3
2
2
2
1
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Immunogen Synthetic peptide corresponding aa 9-26 of human BORIS protein
Isotype IgG
Specificity This antibody is directed against the BORIS protein.
Cross-Reactivity (Details) Species reactivity (expected):Chimpanzee.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name CTCFL / BORIS (CTCFL Antibody Abstract)
Background BORIS (Brother of the Regulator of Imprinted Sites) also known as CCCTC-binding factor-like protein, is normally only expressed in the testis and expressed in a mutually exclusive manner with CTCF during male germ cell development. However, previous studies have shown that BORIS is abnormally activated in a wide range of human cancers. Expression of BORIS in normally BORIS-negative cells promotes cell growth that may lead to transformation. BORIS maps to the cancer-associated amplification region thought to contain an oncogene or dominant-immortalizing gene. BORIS is a candidate protein for the epigenetic reprogramming factor acting in the male germ line. BORIS is found in both the nucleus and cytoplasm.Synonyms: Brother of the regulator of imprinted sites, CCCTC-binding factor, CT27, CTCF paralog, CTCF-T, CTCF-like protein, Cancer/testis antigen 27, Transcriptional repressor CTCFL, Zinc finger protein CTCF-T
Gene ID 140690
NCBI Accession NP_542185
UniProt Q8NI51
Pathways
Application Notes ELISA: 1/2,000 - 1/10,000. Western Blot: 1/200 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.28 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Supplier Images
 image for anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) (AA 9-26) antibody (ABIN401325) anti-CCCTC-Binding Factor (Zinc Finger Protein)-Like (CTCFL) (AA 9-26) antibody
Background publications Klenova, Morse, Ohlsson et al.: "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer." in: Seminars in cancer biology, Vol. 12, Issue 5, pp. 399-414, 2002 (PubMed).

Loukinov, Pugacheva, Vatolin et al.: "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 10, pp. 6806-11, 2002 (PubMed).