ABCB5 antibody (Internal Region)

Catalog No. ABIN401433

This Rabbit Polyclonal antibody specifically detects ABCB5 in WB and EIA. It exhibits reactivity toward Human and Monkey.

Quick Overview for ABCB5 antibody (Internal Region) (ABIN401433)

Target: ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCB5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ABCB5 Antibody

Binding Specificity: Internal Region

Specificity: This antibody is specific for ABCB5 protein.

Cross-Reactivity (Details): Species reactivity (expected):Monkey (85 %), Rat (68 %), Mouse (62 %).
Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogen: Synthetic peptide corresponding to residues corresponding to an internal region of Human ABCB5

Isotype: IgG

Application Details

Application Notes: ELISA: 1/10,000-1/50,000. Western Blot: 1/20,000. Trial Size: ELISA: 1/10,000- 1/15,000. Western Blot: 1/10,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for ABCB5

Target: ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))

Alternative Name: ABCB5

Background: ATP-Binding Cassette proteins comprise a superfamily of transporters with a wide variety of substrates. ABCB5 is a novel member of the human P-glycoprotein family. It functions as a determinant of membrane potential and regulator of cell fusion in physiologic skin progenitor cells. Cell fusion is thought to contribute to tissue differentiation. ABCB5 is predominantly expressed in melanoma cells and is a novel molecular marker for a distinct subset of chemoresistant stem cell phenotype-expressing tumor cells among human epidermal melanocytes. It has been identified as a novel drug transporter in human malignant melanoma. ABCB5 is a rhodamine efflux transporter. This antibody product is intended to be used to confirm cellular localization and expression level of ABCB5.Synonyms: ATP-binding cassette sub-family B member 5

Gene ID: 340273

NCBI Accession: NP_001157413

UniProt: Q2M3G0