PARP11 antibody (Middle Region)

Catalog No. ABIN404898

The Rabbit Polyclonal anti-PARP11 antibody (ABIN404898) specifically detects PARP11 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig and Rabbit samples.

Quick Overview for PARP11 antibody (Middle Region) (ABIN404898)

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PARP11 Antibody

Binding Specificity: Middle Region

Purpose: PARP11 Antibody - middle region

Sequence: IKHGNTFQIH GVSLQQRHLF RTYKSMFLAR VLIGDYINGD SKYMRPPSKD

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PARP11. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PARP11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33767-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PARP11

Target: PARP11 (Poly (ADP-Ribose) Polymerase Family, Member 11 (PARP11))

Alternative Name: PARP11

Background:

Background Information: PARP1 encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.

Gene Name: Poly (ADP-ribose) polymerase family, member 11

Alternative Symbols: ARTD11, MIB006, C12orf6

Protein Name: Poly [ADP-ribose] polymerase 11

Molecular Weight: 39kDa

Gene ID: 57097

NCBI Accession: NP_065100

UniProt: Q9NR21