ONECUT2 antibody (N-Term)

Catalog No. ABIN405112

This Rabbit Polyclonal antibody specifically detects ONECUT2 in WB. It exhibits reactivity toward Human, Mouse, Guinea Pig and Rat.

Quick Overview for ONECUT2 antibody (N-Term) (ABIN405112)

Target: ONECUT2 (One Cut Homeobox 2 (ONECUT2))

Reactivity: Human, Mouse, Guinea Pig, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ONECUT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ONECUT2 Antibody

Binding Specificity: N-Term

Sequence: TSMASILDGG DYRPELSIPL HHAMSMSCDS SPPGMGMSNT YTTLTPLQPL

Predicted Reactivity: Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ONECUT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ONECUT2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 504 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ONECUT2

Target: ONECUT2 (One Cut Homeobox 2 (ONECUT2))

Alternative Name: ONECUT2

Background: ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism. This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.
Alias Symbols: MGC120377, MGC120378, OC-2, OC2
Protein Interaction Partner: KDM5B,
Protein Size: 504

Molecular Weight: 54 kDa

Gene ID: 9480

NCBI Accession: NM_004852, NP_004843

UniProt: O95948