MNDA antibody (C-Term)

Catalog No. ABIN405140

The Rabbit Polyclonal anti-MNDA antibody is suitable to detect MNDA in samples from Human. It has been validated for WB.

Quick Overview for MNDA antibody (C-Term) (ABIN405140)

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MNDA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MNDA Antibody

Binding Specificity: C-Term

Purpose: MNDA Antibody - C-terminal region

Sequence: KCEKGDKLRL FCLQLRTVDR KLKLVCGSHS FIKVIKAKKN KEGPMNVN

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MNDA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MNDA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38152-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for MNDA

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Alternative Name: MNDA

Background:

Background Information: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage.MNDA may act as a transcriptional activator/repressor in the myeloid lineage. It plays a role in the granulocyte/monocyte cell-specific response to interferon. MNDA stimulates the DNA binding of the transcriptional repressor protein YY1.The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Myeloid cell nuclear differentiation antigen

Alternative Symbols: PYHIN3

Protein Name: Myeloid cell nuclear differentiation antigen

Molecular Weight: 46kDa

Gene ID: 4332

NCBI Accession: NP_002423

UniProt: P41218