SPIC antibody (N-Term)

Catalog No. ABIN405281

The Rabbit Polyclonal anti-SPIC antibody is suitable to detect SPIC in samples from Human, Rat, Cow, Horse, Dog, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for SPIC antibody (N-Term) (ABIN405281)

Target: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Reactivity: Human, Rat, Cow, Horse, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPIC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPIC Antibody

Binding Specificity: N-Term

Purpose: SPIC Antibody - N-terminal region

Sequence: TCVEQDKLGQ AFEDAFEVLR QHSTGDLQYS PDYRNYLALI NHRPHVKGNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SPIC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SPIC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39881-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPIC

Target: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Alternative Name: SPIC

Background:

Background Information: This protein Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression

Gene Name: Spi-C transcription factor (Spi-1/PU.1 related)

Alternative Symbols: SPI-C

Protein Name: Transcription factor Spi-C

Molecular Weight: 29kDa

Gene ID: 121599

NCBI Accession: NP_689536

UniProt: Q8N5J4