Transglutaminase 1, Keratinocyte (TGM1) antibody

Antigen: Transglutaminase 1, Keratinocyte (TGM1)

Synonyms: LI, KTG, LI1, TGK, ICR2, TGASE, TGM1, fa12g12, MGC112355, wu:fa12g12

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine)

Application: Western Blotting (WB)

Catalog no.: ABIN405419

Additional Information

Alternative name: Transglutaminase-1 (TGM1)

Gene ID: TGM1

UniProt: P22735

Immunogen: The immunogen for anti-TGM1 antibody: synthetic peptide directed towards the N terminal of human TGM1

Sequence: RGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGML VVNGVDLLSS

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rabbit, Rat (Rattus)

Format: Lyophilized

Reconstitution: Add 50 µl of distilled water. Final anti-TGM1 antibody concentration is 1 mg/ml.

Description: TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Characteristics: Antigen Size: 817 amino acids

Molecular Weight: 90kDa

Application Details

Application Notes: WB Suggested Anti-TGM1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Transfected 293T.

Purification: Affinity Purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Research Area: Enzymes, Extracellular Matrix

Restrictions: For Research Use only

Images

WB Suggested Anti-TGM1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Transfected 293T

Publications

Product: Marietta, Camilleri, Castro et al.: "Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue." in: The Journal of investigative dermatology, Vol. 128, Issue 2, pp. 332-5, 2008 (PubMed).