TMEM48 antibody (Middle Region)

Catalog No. ABIN405807

Cited in 1 publication. The Rabbit Polyclonal anti-TMEM48 antibody (ABIN405807) specifically detects TMEM48 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig and Zebrafish (Danio rerio) samples.

Quick Overview for TMEM48 antibody (Middle Region) (ABIN405807)

Target: TMEM48 (Transmembrane Protein 48 (TMEM48))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM48 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TMEM48 Antibody

Binding Specificity: Middle Region

Purpose: TMEM48 Antibody - middle region

Sequence: PPIIKYLALQ DLMLLSQYSP SRRQEVFSLS QPGGHPHNWT AISRECLNLL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TMEM48. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TMEM48

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46268-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-TMEM48 antibody (ABIN405807)

Tarazón, Rivera, Roselló-Lletí, Molina-Navarro, Sánchez-Lázaro, España, Montero, Lago, González-Juanatey, Portolés: "Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes." in: PLoS ONE, Vol. 7, Issue 11, pp. e48957, (2012) (PubMed).

Target Details for TMEM48

Target: TMEM48 (Transmembrane Protein 48 (TMEM48))

Alternative Name: TMEM48

Background:

Background Information: TMEM48 is a component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. TMEM48 is required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

Gene Name: Transmembrane protein 48

Alternative Symbols: NET3, TMEM48

Protein Name: Nucleoporin NDC1

Molecular Weight: 76 kDa

Gene ID: 55706

NCBI Accession: NP_060557

UniProt: Q9BTX1