Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibody

Details for Product No. ABIN406003
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Antigen
Synonyms BL44, GCK, RAB8IP, AI385662, Rab8ip
Epitope
N-Term
(8), (7), (7), (5), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Zebrafish (Danio rerio), Dog (Canine), Xenopus laevis, Human
(31), (13), (4), (1), (1)
Host
Rabbit
(36), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(37), (24), (8), (6), (3), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN406003
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Immunogen Synthetic peptide directed towards the N terminal of human MAP4K2
Sequence HLHPMRALML MSKSSFQPPK LRDKTRWTQN FHHFLKLALT KNPKKRPTAE
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Dog : 90 %, Pig : 90 %, Guinea pig : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against MAP4K2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MAP4K2
Background MAP4K2 is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.
Molecular Weight 91 kDa
Gene ID 5871
NCBI Accession NP_004570, NM_004579
UniProt Q12851
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 820 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

Validation Images
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