CENPP antibody (N-Term)

Catalog No. ABIN406399

This Rabbit Polyclonal antibody specifically detects CENPP in WB. It exhibits reactivity toward Human and Horse.

Quick Overview for CENPP antibody (N-Term) (ABIN406399)

Target: CENPP (Centromere Protein P (CENPP))

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CENPP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CENPP Antibody

Binding Specificity: N-Term

Purpose: CENPP Antibody - N-terminal region

Sequence: VQKSFQAIHQ FNLEGWKSSK DLKNQLGHLE SELSFLSTLT GINIRNHSKQ

Predicted Reactivity: Horse: 77%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against CENPP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CENPP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54412-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CENPP

Target: CENPP (Centromere Protein P (CENPP))

Alternative Name: CENPP

Background:

Background Information: CENPP is the component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. CENPP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1104 CR592049.1 1-1104 1105-1633 BC071726.1 622-1150 1634-1689 BX537851.1 972-1027 1690-3411 AK091247.1 839-2560 3412-3428 AL833701.1 3078-3094

Gene Name: Centromere protein P

Alternative Symbols: CENP-P

Protein Name: Centromere protein P

Molecular Weight: 33kDa

Gene ID: 401541

NCBI Accession: NP_001012267

UniProt: Q6IPU0