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Details for Product No. ABIN406752

Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) (N-Term) antibody

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Antigen
Synonyms ACHRG, Achr-3, Acrg
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN406752
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-CHRNG antibody: synthetic peptide directed towards the N terminal of human CHRNG
Sequence NYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTN VWIEMQWCDY
Predicted Reactivity Dog : 100%, Human : 100%, Rabbit : 100%, Bovine : 92%, Guinea pig : 92%, Mouse : 85%, Rat : 85%
Characteristics This is a rabbit polyclonal antibody against CHRNG. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name CHRNG
Background For background information on the acetylcholine receptor (AChR), see CHRNA1. Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit, which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity.For background information on the acetylcholine receptor (AChR), see CHRNA1 (MIM 100690). Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit (MIM 100725), which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity, MIM 142445).
Molecular Weight 56kDa
Gene ID 1146
NCBI Accession NP_005190, NM_005199
UniProt P07510
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-CHRNG antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Morgan, Brueton, Cox et al.: "Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome." in: American journal of human genetics, Vol. 79, Issue 2, pp. 390-5, 2006 (PubMed).

Alternatives for antigen "Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG)", type "Antibodies"
Hosts (5), (3)
Reactivities (8)
Applications (8), (3), (3), (2), (1), (1)
Epitopes (4), (2), (1)
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