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Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) (N-Term) antibody

Details for Product No. ABIN406752
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Antigen
Synonyms ACHRG, Achr-3, Acrg
Epitope
N-Term
(9), (7), (2)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Human
(14)
Host
Rabbit
(11), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(14), (6), (3), (3), (3)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN406752
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human CHRNG
Sequence NYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTN VWIEMQWCDY
Predicted Reactivity Dog : 100 %, Human : 100 %, Rabbit : 100 %, Bovine : 90 %, Guinea pig : 90 %, Mouse : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against CHRNG. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CHRNG
Background For background information on the acetylcholine receptor (AChR), see CHRNA1. Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit, which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity.For background information on the acetylcholine receptor (AChR), see CHRNA1 (MIM 100690). Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit (MIM 100725), which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity, MIM 142445).
Molecular Weight 56 kDa
Gene ID 1146
NCBI Accession NM_005199, NP_005190
UniProt P07510
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 517 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) (N-Term) antibody anti-Cholinergic Receptor, Nicotinic, gamma Polypeptide (CHRNG) (N-Term) antibody
Background publications Morgan, Brueton, Cox et al.: "Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome." in: American journal of human genetics, Vol. 79, Issue 2, pp. 390-5, 2006 (PubMed).

Validation Images
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