CSNK1A1 antibody

Catalog No. ABIN437965

This Chicken Polyclonal antibody specifically detects CSNK1A1 in WB, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for CSNK1A1 antibody (ABIN437965)

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This CSNK1A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-CSNK1A1 Antibody

Cross-Reactivity: Human

Immunogen: Human Casein Kinase 1 alpha protein.

Isotype: IgY

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for CSNK1A1

Target: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Background: The CKI family consists of several different genes, divided in alpha, beta, gamma, delta and epsilon, some of which are encoded by more than one gene. The single mammalian CK1 alpha gene can generate four different proteins by alterate transcription. CK1a was raised against the shortest of these proteins, and will therefore bind to all CK1 isotypes. The CK1 alpha proteins are involved in the control of protein degradation, and phosphorylate acidic regions of their substrate molecules. Typically the target ser/thr residues closely C-terminal to two or three aspartic or glutamic acid residues. Alternately, phosphorylation on residues 3 or 4 amino acids N-terminal to a ser/thr residue can also favor CKI phosphorylation. This means that CKI family enzymes often phosphorylate one or more ser/thr residues C-terminal to a phosphorylation site generated by the activity of another protein kinase.

Pathways: WNT Signaling, Hedgehog Signaling