Keratin 13 (KRT13) antibody

Details for Product No. ABIN452448
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Antigen
Synonyms krt13, CK13, K13, Ka13, Krt-1.13, Krt1-13, ck13, k13
Reactivity
Cow (Bovine), Human, Rat (Rattus)
(101), (26), (26), (15), (12), (3), (3), (3), (1), (1), (1)
Host
Mouse
(54), (43), (7), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(80), (47), (26), (24), (22), (22), (12), (10), (8), (4), (1)
Pubmed 5 references available
Quantity 5 mL
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Catalog No. ABIN452448
308.00 $
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Immunogen Keratin K13 of Mr 54.000 purified from Human esophagus
Clone Ks13-1
Isotype IgG1
Specificity This Monoclonal Antibody Ks 13.1 represents an excellent marker to discriminate non- cornified squamous epithelia from those of different origin. Polypeptide Reacting: Mr 54 000 polypeptide Human keratin K13 (formerly designated cytokeratin13, with minor affinity to keratins K14, Mr 50 000, and K16, Mr 48 000). Tumors Specifically Detected: Several squamous cell carcinomas, e.g. cervix carcinoma, transitional cell carcinoma of the bladder, craniopharyngioma. Tested Reactivities on Cultured on Cell Lines: Cell lines from squamous cell CA, e.g. A-431 from epidermoid CA of vulva, RT 112, RT-4 of urinary bladder.
Purification Protein A Affinity Chromatography
Alternative Name Cytokeratin 13
Background Cytokeratin 13 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.
Alternate names: CK-13, CK13, K13, KRT-13, KRT13, Keratin type I cytoskeletal 13, Keratin-13
Gene ID 3860
NCBI Accession NP_002265
UniProt P13646
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Immunofluorescence. Immunohistochemistry on frozen and paraffin sections: Ready-to-use. Immunoblotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4 0.5% BSA 0.09% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Dallenbach-Hellweg, Lang: "Immunohistochemical studies on uterine tumors. I. Invasive squamous cell carcinomas of the cervix and their precursors." in: Pathology, research and practice, Vol. 187, Issue 1, pp. 36-43, 1991 (PubMed).

Dockhorn-Dworniczak, Franke, Schröder et al.: "Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas." in: Differentiation; research in biological diversity, Vol. 35, Issue 1, pp. 53-71, 1988 (PubMed).

Moll, Achtstätter, Becht et al.: "Cytokeratins in normal and malignant transitional epithelium. Maintenance of expression of urothelial differentiation features in transitional cell carcinomas and bladder carcinoma cell culture lines." in: The American journal of pathology, Vol. 132, Issue 1, pp. 123-44, 1988 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Demirkesen, Hoede, Moll: "Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins." in: Journal of cutaneous pathology, Vol. 22, Issue 6, pp. 518-35, 1996 (PubMed).

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