VDAC1 antibody (N-Term)

Catalog No. ABIN453456

The Rabbit Polyclonal anti-VDAC1 antibody (ABIN453456) specifically detects VDAC1 in WB and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for VDAC1 antibody (N-Term) (ABIN453456)

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VDAC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-VDAC1 Antibody

Binding Specificity: N-Term

Specificity: This antibody recognizes VDAC-1.

Purification: Saturated Ammonium Sulfate (SAS) precipitation.

Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of Human VDAC1.

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for VDAC1

Target: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Alternative Name: VDAC1

Background: VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.Synonyms: Mitochondria marker, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC, Voltage-dependent anion-selective channel protein 1

Gene ID: 7416

NCBI Accession: NP_003365

UniProt: P21796