Chemokine (C-C Motif) Receptor 3 (CCR3) antibody

Antigen: Chemokine (C-C Motif) Receptor 3 (CCR3)

Synonyms: CKR3, CD193, CMKBR3, CC-CKR-3, MGC102841

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN453561

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3, Eosinophileotaxin receptor

Alternative name: CD193 / CCR3

Gene ID: 1232

Swiss-Prot: P51677

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human CCR3

Cross-Reactivity: Human

Description: CCR3 is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupledreceptors. This receptor binds and responds to a variety of chemokines, including eotaxin(CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highlyexpressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as wellas in airway epithelial cells. This receptor may contribute to the accumulation andactivation of eosinophils and other inflammatory cells in the allergic airway. It is alsoknown to be an entry co-receptor for HIV-1.

Specificity: This antibody reacts to CD193 / CCR3. Species: Human. Others not tested.

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 0.25 mg/ml

Buffer: PBS with 0.09% (W/V) sodium azide

Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Chemokines, Receptors, CD Antigens

Restrictions: For Research Use only