IL16 antibody clone 323 exhibits no detectable cross-reacting with human albumin serum, Bovine albumin serum and other human cytokines or growth factors tested such as IL-1beta, IL-8, IL-7 MCAF, TGF-beta 1, EGF, bFGF, GM-CSF, M-CSF, TNF-alpha.
Interleukin-16 (IL16) is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils.Synonyms: IL-16, LCF, Lymphocyte chemoattractant factor