PACAP antibody (C-Term)

Catalog No. ABIN453980

Product Details anti-PACAP Antibody

Target: PACAP (ADCYAP1) (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig

Host: Goat

Clonality: Polyclonal

Conjugate: This PACAP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-GKRYKQRVKN KGRR

Specificity: This antibody detects PACAP at C-term.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine, Porcine.
Species reactivity (tested):Human.

Purification: Antigen Affinity Chromatography

Immunogen: Synthetic peptide with sequence from the C-Terminus of Human ADCYAP1 (NP_001108.2). Genename: ADCYAP1

Application Details

Application Notes: Peptide ELISA: 1/2000. Western blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for PACAP

Target: PACAP (ADCYAP1) (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) (ADCYAP1))

Alternative Name: ADCYAP1 / PACAP (ADCYAP1 Products)

Background: Adenylate cyclase activating polypeptide, mediated by adenylate cyclase activating polypeptide 1 receptors, stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase activating polypeptide 1 is not only a hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. The gene encodes three different mature peptides, including two isotypes: a shorter form and a longer form.Synonyms: Pituitary adenylate cyclase-activating polypeptide

Gene ID: 116

NCBI Accession: NP_001108

UniProt: P18509

Pathways: Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Activity, cAMP Metabolic Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, Regulation of G-Protein Coupled Receptor Protein Signaling