Sirtuin 7 (SIRT7) (Middle Region) antibody

Details for Product No. ABIN486930
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Antigen
Synonyms SIRT7, LOC796135, SIR2L7
Epitope
Middle Region
(14), (9), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human
(59), (33), (30), (15), (14), (12), (3)
Host
Rabbit
(56), (8), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(55), (26), (15), (14), (10), (6), (5), (3), (3), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN486930
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human SIRT7
Sequence GEEGSHSRKS LCRSREEAPP GDRGAPLSSA PILGGWFGRG CTKRTKRKKV
Predicted Reactivity Human : 100 %, Bovine : 80 %, Horse : 80 %, Dog : 70 %
Characteristics This is a rabbit polyclonal antibody against SIRT7. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SIRT7
Background SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Molecular Weight 45 kDa
Gene ID 51547
NCBI Accession NP_057622, NM_016538
UniProt Q9NRC8
Research Area Cancer, Chromatin Binding Proteins, Transcription Factors, Proteases
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 400 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Sirtuin 7 (SIRT7) (Middle Region) antibody WB Suggested Anti-SIRT7 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: SH-SYSY cell lysate
Background publications Ashraf, Zino, Macintyre et al.: "Altered sirtuin expression is associated with node-positive breast cancer." in: British journal of cancer, Vol. 95, Issue 8, pp. 1056-61, 2006 (PubMed).

Validation Images
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