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Details for Product No. ABIN486930

Sirtuin 7 (SIRT7) (Middle Region) antibody

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Antigen
Synonyms SIR2L7, SIRT7, LOC796135
Epitope
»Alternatives Middle Region
Reactivity
»Alternatives Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN486930
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-SIRT7 antibody: synthetic peptide directed towards the middle region of human SIRT7
Sequence GEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRG CTKRTKRKKV
Predicted Reactivity Human : 100%, Bovine : 85%, Horse : 85%, Dog : 78%
Characteristics This is a rabbit polyclonal antibody against SIRT7. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name SIRT7
Background SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Molecular Weight 45kDa
Gene ID 51547
NCBI Accession NP_057622, NM_016538
UniProt Q9NRC8
Research Area Cancer, Chromatin Binding Proteins, Transcription Factors, Proteases
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-SIRT7 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Ashraf, Zino, Macintyre et al.: "Altered sirtuin expression is associated with node-positive breast cancer." in: British journal of cancer, Vol. 95, Issue 8, pp. 1056-61, 2006 (PubMed).

Alternatives for antigen "Sirtuin 7 (SIRT7)", type "Antibodies"
Hosts (52), (9), (3)
Reactivities (56), (33), (31), (13), (13), (12), (1)
Applications (50), (24), (13), (10), (9), (7), (3), (2), (2), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (3), (3), (2), (2), (1), (1), (1)
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