Sirtuin 7 (SIRT7) antibody

Antigen: Sirtuin 7 (SIRT7)

Synonyms: SIR2L7, MGC126840, MGC126842, SIRT7, MGC142712, LOC796135

Clonality: Polyclonal

Host: Rabbit

Reactivity: Cow (Bovine), Human, Dog (Canine)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN486930

Additional Information

Alternative name: SIRT7

Gene ID: SIRT7

UniProt: Q9NRC8

Immunogen: The immunogen for anti-SIRT7 antibody: synthetic peptide directed towards the middle region of human SIRT7

Sequence: GEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRG CTKRTKRKKV

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human

Format: Lyophilized

Reconstitution: Add 50 µl of distilled water. Final anti-SIRT7 antibody concentration is 1 mg/ml.

Description: SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT7 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Characteristics: Antigen Size: 400 amino acids

Molecular Weight: 45kDa

Application Details

Application Notes: WB Suggested Anti-SIRT7 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: SH-SYSY cell lysate.

Purification: Affinity Purified

Buffer: PBS

Storage (Long Term): For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Storage (Short Term): Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.

Research Area: Cancer, Chromatin Binding Proteins, Transcription Factors, Proteases

Restrictions: For Research Use only

Images

WB Suggested Anti-SIRT7 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: SH-SYSY cell lysate

Publications

Product: Ashraf, Zino, Macintyre et al.: "Altered sirtuin expression is associated with node-positive breast cancer." in: British journal of cancer, Vol. 95, Issue 8, pp. 1056-61, 2006 (PubMed).