Chemokine (C-C Motif) Receptor 4 (CCR4) antibody

Antigen: Chemokine (C-C Motif) Receptor 4 (CCR4)

Synonyms: CKR4, K5-5, CD194, CMKBR4, ChemR13, CC-CKR-4, MGC88293, HGCN:14099

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN488046

Additional Information

Characteristics: Synonyms: C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CMKBR4, K5-5

Alternative name: CD194 / CCR4

Gene ID: 4887

Swiss-Prot: P51679

Immunogen: Synthetic peptide – KLH conjugated. Epitope: C-terminal domain of Human. Remarks: Mouse Homology: 72% (Identity) / 77% (Similarity). Rat Homology: 77% (Identity) / 83% (Similarity).

Cross-Reactivity: Human

Description: Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and theDuffy blood group antigen. The C - C receptors are important in the function of T cellchemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 ispreferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokinereceptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased followingTCR and CD28 engagement. Moreover, activated Th1 cells up regulate CCR4 expression andfunctional responsiveness to thymus- and activation-regulated chemokine. CCR4 mediates inflammatory responses and HIV-1 infections. It binds beta-familychemokines (CC motif) such as TARC (thymus and activation-regulated chemokine) andMDC (macrophage-derived chemokine).

Specificity: Recognizes C-C Chemokine Receptor 4 (CCR4/CD194). Species Reactivity: Tested: Human. Add. Information: This product was originally produced by MBL International.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Purification: Aff - Purified

Buffer: PBS containing 0.09% Sodium Azide as preservative.

Storage: Store the antibody undiluted at 2-8°C for one monthor (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Chemokines, Receptors

Restrictions: For Research Use only