SOCS5 antibody (N-Term)

Catalog No. ABIN488053

This Rabbit Polyclonal antibody specifically detects SOCS5 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for SOCS5 antibody (N-Term) (ABIN488053)

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SOCS5 Antibody

Binding Specificity: AA 1-11, N-Term

Specificity: Recognizes Suppressor of Cytokine Signaling 5 (SOCS5).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Antigen-Affinity Chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 11 of SOCS5.

Application Details

Application Notes: Western blotting: 1/500-1/3000. Immunohistochemistry on Paraffin Sections: 1/100-1/500. Positive Controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 1 x PBS, 40 % Glycerol ( pH 7) containing 0.01 % Thimerosal as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C.

Target Details for SOCS5

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Alternative Name: SOCS5 / CIS6

Background: The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.Synonyms: CIS-6, CISH5, CISH6, Cytokine-inducible SH2 protein 6, Cytokine-inducible SH2-containing protein 5, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5

Gene ID: 9655, 9606

UniProt: O75159

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process