TNFRSF10A antibody (Extracellular Domain) (PE)

Catalog No. ABIN488159

The Mouse Monoclonal anti-TNFRSF10A antibody is suitable to detect TNFRSF10A in samples from Human. It has been validated for FACS.

Quick Overview for TNFRSF10A antibody (Extracellular Domain) (PE) (ABIN488159)

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10A antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: DR-4-02

Product Details anti-TNFRSF10A Antibody (PE)

Binding Specificity: Extracellular Domain

Specificity: The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a Human Death Receptor 4 (468 amino acids) expressed in most Human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A, Tumor necrosis factorreceptor superfamily member 10A, TNF-related apoptosis-inducing ligand receptor 1

Purification: Size-Exclusion Chromatography.

Immunogen: Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of theheavy chain of the Human IgG1.

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry analysis: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 15 mM sodium azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: CD261 / TRAILR1

Background: TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).Synonyms: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A

Gene ID: 8797

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity