UBA52 antibody (C-Term)

Catalog No. ABIN498041

The Rabbit Polyclonal anti-UBA52 antibody is suitable to detect UBA52 in samples from Human. It has been validated for WB, IHC (p) and EIA.

Quick Overview for UBA52 antibody (C-Term) (ABIN498041)

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBA52 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-UBA52 Antibody

Binding Specificity: C-Term

Specificity: Recognizes Ubiquitin, Ribosomal Protein L40 (UBA52).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein G Chromatography

Immunogen: Synthetic peptide kLH conjugated synthetic peptide selected from the C-terminal region of Human Ubiquitin .Remarks: Antigen Modification: C-Terminus

Isotype: IgG

Application Details

Application Notes: ELISA: 1/50-1/100Western blot: 1/100-1/500Immunohistochemistry on Paraffin Sections: 10 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for UBA52

Target: UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))

Alternative Name: UBA52

Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.Synonyms: CEP52, UBCEP2, Ubiquitin A-52 residue ribosomal protein fusion product 1, Ubiquitin-60S ribosomal protein L40

Gene ID: 7311

NCBI Accession: NP_001029102

UniProt: P62987

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation