FOXE1 antibody

Catalog No. ABIN498296

The Rabbit Polyclonal anti-FOXE1 antibody is suitable to detect FOXE1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC (p).

Quick Overview for FOXE1 antibody (ABIN498296)

Target: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FOXE1 Antibody

Specificity: FoxE1 pAb detects endogenous levels of FoxE1 protein. (region surrounding Gln11)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity-chromatography using epitope-specific immunogen

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FOXE1

Target: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Alternative Name: FOXE1 / FKHL15

Background: This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.Synonyms: FOXE2, Forkhead box protein E1, HFKH4, HFKL5, HNF-3/fork head-like protein 5, TITF2, TTF-2, TTF2, Thyroid transcription factor 2

Molecular Weight: approx. 34 kDa

Gene ID: 2304

NCBI Accession: NP_004464

UniProt: O00358