LMX1B antibody

Catalog No. ABIN498413

The Rabbit Polyclonal anti-LMX1B antibody is suitable to detect LMX1B in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for LMX1B antibody (ABIN498413)

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMX1B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-LMX1B Antibody

Specificity: This antibody detects endogenous levels of LMX1B protein. (region surrounding Asp159)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for LMX1B

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Alternative Name: LMX1B

Background: The Lim class homeobox gene Lmx1b is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.Synonyms: LIM homeobox transcription factor 1-beta, LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX-1.2, LMX1B

Molecular Weight: approx. 42 kDa

Gene ID: 4010

NCBI Accession: NP_002307

UniProt: O60663

Pathways: Dopaminergic Neurogenesis