IL4 Receptor antibody

Catalog No. ABIN498468

The Rabbit Polyclonal anti-IL4 Receptor antibody (ABIN498468) specifically detects IL4 Receptor in IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for IL4 Receptor antibody (ABIN498468)

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL4 Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL4 Receptor Antibody

Specificity: This antibody detects endogenous levels of IL-4Ralpha protein. (region surrounding Ser254)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Alternative Name: CD124 / IL4R

Background: The IL-2 receptor is a multicomponent complex consisting of three subunits, alpha, beta and gamma, each of which is required for high affinity binding of IL-2. The alpha chain functions primarily in binding IL-2, whereas the beta and gamma chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2Rgamma chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Ralpha and IL-7Ralpha, respectively, while the common subunit is referred to as gammac. Although the common gamma chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the gammac chain is also a subunit of IL-13R.Synonyms: 582J2.1, IL-4R-alpha, IL4 Receptor alpha, IL4RA, Interleukin-4 receptor alpha chain

Molecular Weight: approx. 88 kDa

Gene ID: 3566

NCBI Accession: NP_000409

UniProt: P24394

Pathways: JAK-STAT Signaling, Positive Regulation of Immune Effector Process