SERPINB2 antibody

Catalog No. ABIN498689

The Rabbit Polyclonal anti-SERPINB2 antibody is suitable to detect SERPINB2 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for SERPINB2 antibody (ABIN498689)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SERPINB2 Antibody

Specificity: This antibody detects endogenous levels of PAI-2 protein. (region surrounding Val307)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Alternative Name: SERPINB2 / PAI2

Target Type: Amino Acid

Background: PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.Synonyms: Monocyte Arg-serpin, PAI-2, PLANH2, Placental plasminogen activator inhibitor, Plasminogen activator inhibitor 2, Serpin B2, Urokinase inhibitor

Molecular Weight: approx. 45 kDa

Gene ID: 5055

NCBI Accession: NP_001137290

UniProt: P05120

Pathways: Autophagy