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CrkL antibody (pTyr207)
CRKL
Reactivity: Human, Mouse, Rat
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CrkL Antibody
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Target
See all CrkL (CRKL) Antibodies
CrkL (CRKL)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
Binding Specificity
All epitopes for CrkL antibodies
pTyr207
Reactivity
All reactivities for CrkL antibodies
Human, Mouse, Rat
Host
All hosts for CrkL antibodies
Rabbit
Clonality
All clonalities for CrkL antibodies
Polyclonal
Conjugate
All conjugates for CrkL antibodies
This CrkL antibody is un-conjugated
Application
All applications for CrkL antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody detects endogenous levels of p-CrkL protein only when phosphorylated at Try207.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CrkL
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Target
CrkL (CRKL)
(V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
Alternative Name
CRKL (CRKL Products )
Synonyms
CRKL antibody, wu:fa55g05 antibody, wu:fj60e01 antibody, zgc:63469 antibody, 1110025F07Rik antibody, AA589403 antibody, AI325100 antibody, Crkol antibody, CRK like proto-oncogene, adaptor protein antibody, v-crk avian sarcoma virus CT10 oncogene homolog-like antibody, CRKL antibody, crkl antibody, Crkl antibody
Background
Crk, is a transformation-specific protein that induces elevation of cellular phosphotyrosine levels, but lacks tyrosine kinase activity itself. A second protein, Nck, consists solely of three SH3 domains and one SH2 domain, while GRB2 contains an SH2 domain flanked on both sides by SH3 domains. A member of this protein class, Crk-L, is encoded by a gene located on chromosome 22, band 11, centromeric of the chronic myelogenous leukemia breakpoint region. Crk-L encodes a 303 amino acid protein with one SH2 and two SH3 domains, and a predicted molecular weight of 36 kDa.Synonyms: Crk-like protein, v-crk avian sarcoma virus CT10 oncogene homolog-like
Molecular Weight
approx. 39 kDa
Gene ID
1399
NCBI Accession
NP_005198
UniProt
P46109
Pathways
Interferon-gamma Pathway , Neurotrophin Signaling Pathway , Signaling of Hepatocyte Growth Factor Receptor
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