Apoptotic Chromatin Condensation Inducer 1 (ACIN1) antibody

Details for Product No. ABIN499197
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Antigen
Synonyms
ACINUS, ACN, fSAP152, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb6 ... show more
ACINUS, ACN, fSAP152, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn show less
Reactivity
Human
(130), (41), (26), (24), (24), (12)
Host
Rabbit
(129), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(113), (46), (34), (20), (12), (10), (7), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN499197
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
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Immunogen Human Acinus (CP) Peptide AP30010CP-N.
Isotype IgG
Specificity Acinus antibody was raised against a peptide corresponding to amino acids near the C- terminus of the cleaved active peptide p17, which are identical to those of mouse Acinus.
Purification Affinity chromatography purified via peptide column
Alternative Name Acinus / ACIN1
Background Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE . A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS (2).
Alternate names: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
NCBI Accession AAD56724
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Acinus antibody can be used for detection of Acinus at 0.5 to 1 μg/ml. Anapproximate 220 kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zamzami, Kroemer: "Condensed matter in cell death." in: Nature, Vol. 401, Issue 6749, pp. 127-8, 1999 (PubMed).

Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Hosts (129), (6)
Reactivities (130), (41), (26), (24), (24), (12)
Applications (113), (46), (34), (20), (12), (10), (7), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (32), (17), (12), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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