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Details for Product No. ABIN499203

Apoptotic Chromatin Condensation Inducer 1 (ACIN1) antibody

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Antigen
Synonyms
ACINUS, ACN, fSAP152, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb6 ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN499203
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human Acinus Peptide (AP30013CP-N)
Isotype IgG
Specificity Acinus antibody was raised against a peptide corresponding to amino acids 994 to 1009 of human AcinusL, 267 to 282 of human AcinusS’, or 236 to 251 of human AcinusS, which are identical to those of mouse Acinus. The selected antigenic sequence is located near the N- terminus of active peptide p17.
Purification Affinity chromatography purified via peptide column
Alternative Name Acinus / ACIN1
Background Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS (2)
Alternate names: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
NCBI Accession AAD56724
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Acinus antibody can be used for detection of acinus at 0.5 to 1 μg/ml. Anapproximate 220 kDa band can be detected. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Zamzami, Kroemer: "Condensed matter in cell death." in: Nature, Vol. 401, Issue 6749, pp. 127-8, 1999 (PubMed).

Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Alternatives for antigen "Apoptotic Chromatin Condensation Inducer 1 (ACIN1)", type "Antibodies"
Hosts (131), (6)
Reactivities (130), (40), (25), (24), (24), (12)
Applications (115), (40), (35), (20), (13), (12), (8), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (35), (19), (12), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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