TNFSF13 antibody (Extracellular Domain)

Catalog No. ABIN499325

The Rabbit Polyclonal anti-TNFSF13 antibody is suitable to detect TNFSF13 in samples from Human and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for TNFSF13 antibody (Extracellular Domain) (ABIN499325)

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TNFSF13 Antibody

Binding Specificity: Extracellular Domain

Specificity: APRIL antibody was raised against a synthetic peptide corresponding to amino acids within an extracellular domain of human APRIL.

Purification: Affinity Chromatography

Immunogen: Human APRIL (Extracellular Domain 2) Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: APRIL antibody can be used for detection of APRIL at 1-4 μg/mL. Jurkat cell lysate was used as a positive control and a 27 kDa band was detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TNFSF13

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Alternative Name: CD256 / APRIL

Background: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identified and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kappaB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9).Synonyms: A proliferation-inducing ligand, TALL-2, TALL2, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TNFSF13, TRDL-1, Tumor necrosis factor ligand superfamily member 13, ZTNF2

Gene ID: 8741

NCBI Accession: NP_003799

UniProt: O75888

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response