ADP-Ribosylation Factor-Like 6 Interacting Protein 1 (ARL6IP1) (C-Term) antibody

Details for Product No. ABIN499337
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Antigen
Synonyms arl6ip, MGC56593, zgc:56593, zgc:77873, ARL6IP, aip1, armer, ARL6IP1, MGC85055, MGC139614, DKFZp459O112, AIP1, ARMER, AIP-6, AL022945, AU042858, Aip-1, Arl6ip, C85138, mKIAA0069
Epitope
C-Term
(16), (14), (8), (4), (1), (1)
Reactivity
Human, Mouse (Murine)
(51), (28), (19)
Host
Rabbit
(49), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(43), (22), (14), (9), (8), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN499337
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Immunogen Human ARMER / ARL6IP / AIP1 (C-Terminus) Peptide
Isotype IgG
Specificity ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
Purification Ion exchange chromatography
Alternative Name ARL6IP1
Background Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.Synonyms: ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1, Aip-1, KIAA0069
Gene ID 23204
UniProt Q15041
Application Notes ELISA. Western Blot: ARMER antibody can be used for detection of ARMER at 0.5 to 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Steller: "Mechanisms and genes of cellular suicide." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1445-9, 1995 (PubMed).

Nakagawa, Zhu, Morishima et al.: "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta." in: Nature, Vol. 403, Issue 6765, pp. 98-103, 2000 (PubMed).

Lui, Chen, Wang et al.: "ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis." in: Molecular cancer research : MCR, Vol. 1, Issue 7, pp. 508-18, 2003 (PubMed).

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