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anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody

Details for Product No. ABIN499365
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Antigen
Synonyms ANTXR1, ATR, TEM8, 2310008J16Rik, 2810405N18Rik, Antrx1, Tem8
Epitope
C-Term
(16), (15), (7), (6), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(100), (42), (38), (13), (12), (1)
Host
Rabbit
(93), (8), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(55), (40), (24), (24), (19), (13), (11), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN499365
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Immunogen Human ATR / TEM8 (C-Terminus) Peptide (AP30097CP-N)
Isotype IgG
Specificity ATR antibody was raised against a peptide corresponding to 13 amino acids near the C- terminus of human ATR. ATR will recognize only the largest isoform.
Purification Ion exchange chromatography
Alternative Name Anthrax toxin receptor 1
Background The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) (1). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin (2). Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) (3). This complex is then endocytosed by the cell, acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis (4).
Alternate names: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
Gene ID 84168
NCBI Accession NP_444262
UniProt Q9H6X2
Research Area Toxins, Receptors
Application Notes ELISA. Western Blot: ATR antibody can be used for detection of ATR by Western blot at 1 to 2μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Molloy, Bresnahan, Leppla et al.: "Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen." in: The Journal of biological chemistry, Vol. 267, Issue 23, pp. 16396-402, 1992 (PubMed).

Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

Duesbery, Webb, Leppla et al.: "Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor." in: Science (New York, N.Y.), Vol. 280, Issue 5364, pp. 734-7, 1998 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Bradley, Mogridge, Mourez et al.: "Identification of the cellular receptor for anthrax toxin." in: Nature, Vol. 414, Issue 6860, pp. 225-9, 2001 (PubMed).

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