You are viewing an incomplete version of our website. Please click to reload the website as full version.

TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody

Details for Product No. ABIN499531, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms CARABIN, EPI64C, 1810062O14Rik, AI428527, RGD1311490
(16), (7), (5), (1)
Human, Mouse (Murine)
(35), (16), (5), (5), (3), (2), (1), (1)
(28), (8)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(30), (21), (13), (3), (1)
Pubmed 4 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Carabin antibody was raised against a 17 amino acid peptide from near the amino terminus of human Carabin.
Isotype IgG
Specificity This antibody reacts to Carabin.
Purification Affinity chromatography purified via peptide column
Alternative Name Carabin (TBC1D10C Antibody Abstract)
Background Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.Synonyms: TBC1 domain family member 10C, TBC1D10C
Gene ID 374403
NCBI Accession NP_940919
UniProt Q8IV04
Application Notes ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody (ABIN499531) Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 μ...
Western Blotting (WB) image for anti-TBC1 Domain Family, Member 10C (TBC1D10C) (N-Term) antibody (ABIN499531) Western blot analysis of Carabin in human spleen tissue lysate with AP30182PU-N Carab...
Background publications Pan, Sun, Kardian et al.: "Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin." in: Nature, Vol. 445, Issue 7126, pp. 433-6, 2007 (PubMed).

Weil, Israël: "Deciphering the pathway from the TCR to NF-kappaB." in: Cell death and differentiation, Vol. 13, Issue 5, pp. 826-33, 2006 (PubMed).

Im, Rao: "Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling." in: Molecules and cells, Vol. 18, Issue 1, pp. 1-9, 2004 (PubMed).

White, Pasztor, Richardson et al.: "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4." in: Cytogenetics and cell genetics, Vol. 89, Issue 3-4, pp. 272-5, 2000 (PubMed).

Catalog No. ABIN499531
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)