Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (Intermediate Domain) antibody

Details for Product No. ABIN499569
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Epitope
Intermediate Domain
(49), (33), (23), (12), (12), (7), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(196), (92), (77), (13), (6), (2), (1)
Host
Rabbit
(180), (29), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(171), (95), (64), (49), (40), (29), (21), (13), (8), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499569
401.50 $
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Immunogen Human Casp-6 / Mch2 (Intermediate Domain) Peptide (AP30201CP-N)
Isotype IgG
Specificity Caspase-6 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-6.
Purification Immunoaffinity
Alternative Name Caspase-6
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).
Alternate names: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
NCBI Accession NP_001217
UniProt P55212
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Casp-6 antibody can be used for the detection of Caspase-6 at 1 μg/ml. MCF7cell lysate can be used as positive control. Depending on cell lines or tissues used, eitherfull-length or other cleavage products may be observed. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).

Wolf, Green: "Suicidal tendencies: apoptotic cell death by caspase family proteinases." in: The Journal of biological chemistry, Vol. 274, Issue 29, pp. 20049-52, 1999 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Zhivotovsky, Orrenius: "Caspase-2 function in response to DNA damage." in: Biochemical and biophysical research communications, Vol. 331, Issue 3, pp. 859-67, 2005 (PubMed).

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